GadoSpin™ MRI agents - from structure to pharmacology
April
18
2012

GadoSpin™ and FeraSpin™ contrast agents make up the first and only portfolio tailored for pre-clinical MRI.
Our product range includes agents that have been designed specifically for indications such as oncology, inflammatory and cardiovascular disease:

GadoSpin Mis our all-purpose extracellular gadolinium chelate agent for classical contrast-enhanced MRI and for studying CNS disease. The trusted standard from human clinical MRI has been formulated for small animal imaging.

GadoSpin Pis a long-circulating imaging agent for magnetic resonance angiography (MRA). It is based on a high-molecular-weight polymer that does not extravasate from intact blood vessels.

GadoSpin Dis a unique dendritic MRI agent for studying blood vessel integrity and angiogenesis in tumors and inflamed tissue via dynamic contrast-enhanced (DCE) MRI. It contains 24 gadolinium ions in a perfectly globular structure.

GadoSpin Fis a unique MRI agent specific for atherosclerosis. It contains a hydrophobic targeting moiety for high protein binding affinity. The agent accumulates in atherosclerotic plaques and enables direct T1-weighted visualization of plaque burden.

GadoSpin™ D, MRI contrast agent

Product

Applications

order no.

GadoSpin D

Small animal MRI of vasculature and dynamic contrast-enhanced (DCE) MRI

130-095-164
130-095-165

 

GadoSpin™ F, MRI contrast agent

Product

Applications

order no.

     

GadoSpin F

Small animal MRI of atherosclerosis and MR angiography

130-095-162
130-095-163

 

GadoSpin™ P, MRI contrast agent

Product

Applications

order no.

     

GadoSpin P

Small animal MRI angiography

130-095-136
130-095-137

 

GadoSpin™ M, MRI contrast agent

Product

Applications

order no.

     

GadoSpin M

Small animal MRI of the extracellular space

130-095-134
130-095-135